WebJun 7, 2024 · TMEM16F, a Ca 2+-activated phospholipid scramblase (CaPLSase), is critical for placental trophoblast syncytialization, HIV infection, and SARS-CoV2-mediated syncytialization, however, how TMEM16F is activated during cell fusion is unclear.Here, using trophoblasts as a model for cell fusion, we demonstrate that Ca 2+ influx through … WebAug 17, 2024 · Deletion of TMEM16F or dynamins blocks expansion, with loss of dynamin expression generating a maximally expanded basal plasma membrane state. Re-expression of dynamin2 or its GTPase-inactivated ...
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WebAug 6, 2024 · TMEM16F displays one of the broadest expression profiles, implying its involvement in multiple physiological processes. 73, 74 The role of TMEM16F in lipid signaling is highlighted by its involvement in phosphatidylserine (PS) exposure in activated platelets during blood coagulation. 13, 75, 76 Consistently, splicing mutations leading to … WebThe TMEM16 protein family has 10 members, each of which carries 10 transmembrane segments. TMEM16A and 16B are Ca 2+-activated Cl − channels. Several other members, including TMEM16F, promote phospholipid scrambling between the inner and outer leaflets of a cell membrane in response to intracellular Ca 2+.However, the mechanism by which … WebRaleigh/Durham Location: 2525 Whilden Drive Durham, NC 27713 919-246-8514 Charlotte Location: 3410 Oak Lake Blvd. Charlotte, NC 28208 704-909-4791 laptop hinges issue