WebJun 17, 2011 · Retinol-binding protein 4 (RBP4), the specific transport protein for retinol (vitamin A) in the blood (), is a novel adipokine that is secreted from adipocytes and hepatocytes.Although studies in mice have suggested that elevated RBP4 levels may play a causal role in the development of insulin resistance and type 2 diabetes, previous studies … WebJul 31, 2024 · Abstract. Retinol binding protein 4 (RBP4), as an adipokine, has been identified to be associated with several types of cancer. However, no studies have assessed its effect on non-small cell lung cancer (NSCLC) risk. The objective of this study was to assess the association between serum RBP4 levels and the risk of NSCLC.
Retinol-binding protein-4 and nonalcoholic fatty liver disease
WebThis protein binds retinol with a kdvalue of ~109 nM. It has similar affinities for 13-cisand 9-cis-retinol. This CRBP3 functions as a substrate for lecithin:retinol acyltransferase (LRAT), and seems necessary for optimal incorporation of RE into milk, as demonstrated by knocking out its gene [205]. WebThe retinol-binding protein. Vitamin A is transported from its storage site in the liver to the epithelial tissues by a carrier protein, the Retinol-binding protein (RBP). In plasma RBP … assassinat de john lennon
Plasma Retinol Binding Protein - an overview - ScienceDirect
WebThe deduced 317-amino acid RODH4 protein has features of the short-chain dehydrogenase/reductase family of enzymes. Human RODH4 shares 73% amino acid identity with mouse cis-retinol/androgen dehydrogenase (CRAD) and 71-72% identity rat Rodh proteins. Topologic analysis predicted that RODH4 contains 4 potential … WebThe Retinol Binding Site. All-trans-retinol binds with the isoprene tail fully extended in the β-barrel with the trimethyl cyclohexylene ring innermost in a hand-in-glove-like fit in a hydrophobic cavity.Aromatic amino acids dominate at the ring end of the ligand. The ligand hydroxyl is at the protein surface and is solvent accessible. WebFeb 1, 2004 · The serum concentration of retinol-binding protein (RBP), the carrier for retinol in the blood, has been proposed as a surrogate measure for serum retinol ( 3 ). RBP is a 21-kDa protein synthesized by the liver and released … la maison romaine youtube