Cisplatin prehydration
WebCisplatin (CDDP) is one of the most active antineoplastic drugs prescribed to treat various solid tumors, including lung, gastric, head and neck, and bladder cancers. ... with or without an aprepitant, and was given before chemotherapy. For prehydration and posthydration, 5 mEq potassium chloride and 4 mEq magnesium sulfate in 500 mL of half ... WebMannitol combined with hydration significantly prevented cisplatin-induced nephrotoxicity. Additionally, mannitol should be particularly considered among patients with cancer, treated with cisplatin > 80 mg/m2, or patients receiving concomitant radiation.
Cisplatin prehydration
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WebSep 4, 2013 · Cisplatin was administered with pre- and post-hydration containing 10 mEq of potassium chloride in 500 ml of fluid over a 60-min period. Immediately before the … WebRepetitive doses of intravenous (IV) metoclopramide, 2 mg/kg in 75 ml 5% dextrose in water over 15 minutes was given 30 minutes prior to, and at 1 1/2, 4 1/2, and 7 1/2 hours after beginning cisplatin chemotherapy. Only patients with nausea and/or vomiting received subsequent doses of 2 mg/kg metoclopramide IV every 3 hours as needed.
WebCis-diamminedichloroplatinum II (cisplatin), a divalent platinum compound and potent cell-cycle nonspecific chemotherapeutic agent, produces a dose-limiting, permanent, high-frequency sensori-neural hearing loss and peripheral neuropathy, and a dose-related cumulative renal insufficiency with tubular necrosis and interstitial nephritis. http://www.bccancer.bc.ca/chemotherapy-protocols-site/Documents/Neuro-Oncology/CNCCV_Protocol.pdf
Web(b) Preparation of cisplatin infusion:DBL Cisplatin Injection should be added to 1 litre of sodium chloride IV infusion 0.9%. (c) Treatment:Following prehydration, administer the … Webpractice in delivery of cisplatin. They should be individualized based on the clinical situation, which may affect the hydration regimen and addition of electrolytes. In children, …
http://www.bccancer.bc.ca/drug-database-site/Drug%20Index/Cisplatin_monograph.pdf
WebAug 24, 2024 · A prospective cohort study evaluated magnesium (15 mEq) supplied as part of a prehydration regimen to 28 patients with cervical cancer receiving treatment with cisplatin. 9 There was no... flowers by suzanne herkimer nyWebDec 4, 2014 · As more than 90% of free cisplatin binds to plasma proteins within 4 h, hydration within that time after initiating treatment is a critical factor in reducing toxicity [ 8 ]. In addition, previous reports have demonstrated that cisplatin-induced Mg depletion may occur in some patients [ 9 ]. flowers by sweetensWebOct 7, 2024 · Cisplatin is one of the most widely used chemotherapeutic drugs in the treatment of a wide range of pediatric and adult malignances. However, it has various side effects which limit its use. Cisplatin mouse models are widely used in studies investigating cisplatin therapeutic and toxic effects. flowers by sweetenWebCisplatin can be detected in urine for weeks after a dose. III. DOSAGE AND ADMINISTRATION A) Administer as a short or long infusion but not IV push. B) Prehydration with 500 mL over 30 min - 2 hours, or 1000 mL NS over 2 - 4 hours. Compound the cisplatin in 500 mL NS and give over 1-2 hr. Post-hydration give 500- … flowers by sylvia richmond hillWebPre-hydration Cisplatin dose < 50mg/m2: N/Saline in 1000ml over 1 hour. If another drug is being given in the regimen e.g. etoposide then this would be used as prehydration i.e. etoposide in 1000ml N/Saline. Cisplatin dose 50mg/m2 < 75mg/m2: N/Saline + KCl 20mmol/L in 1000mls over 1hr plus 100mls 10% mannitol (or equivalent) green apple salon venice fl reviewsWebPreparation of cisplatin infusion: DBL Cisplatin Injection should be added to 1 litre of sodium chloride IV infusion 0.9%. Aluminium containing equipment should not be used for administration of cisplatin (see Section 6.2 Incompatibilities). c. Treatment: Following prehydration, administer the cisplatin infusion over 1-2 hours. flowers by tami chattanooga tnWebJun 23, 2024 · Depending on the protocol, 1 - 2 litres pre-hydration. The patient must have urinated a litre minimum before we proceed. Our cisplat goes in 250 mls usually giving us a final volume of 340 mls. We used to pass Mannitol concurrently but that's now been … flowers by tami chattanooga